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Factors that determine bioalence of two brands of a drug include:

I the taste of the preparations

II the physical appearance of the preparations

III pharmacokinetic parameters of the preparations

A.

I only

B.

III only

C.

I and II only

D.

II and III only

E.

I, II and III

Organisms commonly implicated in the cause of Traveller's Diarrhea include:

I Bacteroides fragilis

II Escherichia coli

III Shigella sp

A.

I only

B.

III only

C.

I and II only

D.

II and III only

E.

I, II and III

Which of the following agents may cause pulmonary toxicity?

I Amiodarone

II Bleomycin

III Ramipril

A.

I only

B.

III only

C.

I and II only

D.

II and III only

E.

I, II and III

The number of milli-alents of lithium that KJ will receive with each dose is:

A.

8

B.

16

C.

24

D.

32

E.

48

Patient has a relevant increase in his asthma symptoms due to environmental allergies. He is currently having salbutamol and fluticasone inhalers. What would you advise as an adjunct medication to treat his symptoms?

A.

Oral corticosteroids

B.

Higher dose of corticosteroid inhalers

C.

Salmeterol

D.

Sodium cromoglycate

E.

Anticholinergic agents

The organophosphates commonly found in insecticides are thought to act by which of the following mechanisms?

A.

Combining with acetylcholine

B.

Potentiating the action of acetylcholinesterase

C.

Forming a very stable complex with acetylcholinesterase

D.

Reacting at the cholinergic receptor

E.

Preventing the release of acetylcholine from the nerve ending

Uricosuric agents are used in gout treatment by inhibiting the uric acid re-absorption in the proximal tubules, the best example of

a uricosuric agent is:

A.

Allopurinol

B.

sulphinpyrazone

C.

Indomethacin

D.

Penicillamine

E.

Methotrexate

Which is the correct start dose of methothrexate in the treatment of rheumatoid arthritis?

A.

7.5mg once a week

B.

15mg once a week

C.

7.5mg daily

D.

15mg daily

E.

22mg once a week

The use of indomethacin in gout treatment:

A.

Inhibit the acute gout arthritis inflammation by inhibition of prostaglandin formation

B.

Inhibits tubulin synthesis

C.

Accelerate renal excretion of uric acid

D.

Inhibit uric acid synthesis

E.

Inhibit the reabsorption of uric acid by the kidney

Drug of choice in the treatment of chronic obstructive pulmonary disease may include:

A.

Salbutamol

B.

Ipratropium

C.

Salmereol

D.

Sodium cromoglycate

E.

Fluticasone