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Side effect of fluvastatin is:

A.

Seizures

B.

Skin rash

C.

Nausea

D.

Urinary tract complications

E.

Myalgia

Which of the following statements refers to bretylium?

A.

May induce mild hypotension and worsen congestive heart failure in some patients. However, most CHF patients can tolerate it.

B.

Duration of action is usually several days.

C.

Has been show to be more effective than six other agents in preventing arrhythmia recurrence and death in patients with ventricular tachyarrhythmias.

D.

Is effective against erythrocytic forms.

E.

Used in emergency setting during attempted resuscitation when lidocaine and cardioversion have failed.

Indication of metoprolol is:

A.

Bacteroides (other than Bacteroides fragilis)

B.

Duodenal ulcer

C.

Stage fright

D.

Ventricular tachyarrythmias provoked by exercise

E.

Cardiac arrest

How much of a 10 mg dose of morphine reaches the systemic circulation given F = .24?

A.

24mg

B.

0.24 mg

C.

2.4 mg

D.

4.1 mg

Class of nelfinavir is:

A.

Glucocorticosteroids

B.

Anti-asthmatic agents

C.

Polyenes

D.

Antivirals

E.

Autonomic nervous system drugs

Mechanism of action of FK506 is:

A.

Reduces calcium influx into neurons

B.

Inhibits calcineurin

C.

Inhibits phospholipase C

D.

Inhibits phospholipid synthesis

E.

Induces DNA damage under anaerobic conditions

Mechanism of action of vancomycin is:

A.

Potentiates glucose-mediated insulin secretion

B.

Inhibits phospholipase C

C.

Mitotic spindle poison

D.

Inhibits transpeptidase

E.

Inhibits bacterial cell wall synthesis

Potassium sparing diuretics have the primary effect upon the _____ found in the kidney.

A.

Proximal convoluted tubule

B.

Loop of Henle

C.

Collecting duct

D.

Distal convoluted tubule

Which of the following statements refers to etidronate?

A.

Binds to DNA, preferentially to GC pairs. Inhibits RNA, DNA, and protein synthesis.

B.

Human, pig, salmon, and eel calcitonins are available.

C.

Is used for both therapy and prophylaxis of influenza A.

D.

Bioavailability increases with administered dose.

E.

Only approved by FDA for hypertension treatment.

For highly polar drugs (e.g. mannitol) what primarily determines elimination rate?

A.

Excretion rate

B.

Metabolism rate

C.

Absorption rate

D.

Distribution rate

E.

All of the above