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What would be the preferred route of metabolism of succinyl choline?

A.

Ester hydrolysis

B.

N-oxidation

C.

Glucuronide conjugation

D.

A & B

E.

All of the above

Which of the following are similarities between Cytochrome P450 and MAO?

A.

Both add oxygen from O2 to substrates and also form water

B.

Both carry out direct heteroatom oxidations

C.

Both carry out oxidative deaminations

D.

Both carry out N-dealkylations

E.

All of the above

Effect of cascara is:

A.

Decreases water absorption

B.

Stimulates segmentation

C.

Decreases meal-stimulated gastric acid secretion

D.

May increase triglycerides

E.

Afterload increase

Which of the following statements refers to phenelzine?

A.

Mechanism of action probably involves NO.

B.

Rapid IV infusion predisposes to neuromuscular paralysis.

C.

May work when other antidepressants fail.

D.

Long half-life.

E.

MOA is inhibited irreversibly. Response occurs when >80% platelet MOA is inhibited.

Mechanism of action of chlorthalidone is:

A.

Mitotic spindle poison

B.

Binds to ergosterol in cell membrane resulting in formation of pores.

C.

Unknown

D.

Induces "freezing" of initiation complex

E.

Inhibits Na-Cl transporter

Side effect of nedocromil is:

A.

Growth retardation in children

B.

Thiocyanate poisoning

C.

Neuromuscular paralysis

D.

Nausea

E.

Dysphonia

Which of the following drugs is associated with the reaction of Cinchonism?

A.

Valproic acid

B.

Quinidine

C.

Isoniazid

D.

Ethosuximide

For the majority of drugs, which of the following equations correctly defines clearance?

A.

Cl = Elimination rate/Cp

B.

Cl = QxE

C.

Cl = .7VD/t1/2

D.

All are correct

Which of the following drugs is associated with the reaction of Stevens-Johnson syndrome?

A.

Valproic acid

B.

Quinidine

C.

Isoniazid

D.

Ethosuximide

Route of administration of methadone is:

A.

Subcutaneous

B.

Inhalation

C.

Intrathecal

D.

Oral

E.

Transdermal